Binding properties of the anti-TB drugs bedaquiline and TBAJ-876 to a mycobacterial F-ATP synthase

Binding properties of the anti-TB drugs bedaquiline and TBAJ-876 to a mycobacterial F-ATP synthase

Tuberculosis (TB), the deadly disease caused by Mycobacterium tuberculosis (Mtb), kills more people worldwide than any other bacterial infectious disease. There has been a recent resurgence of TB drug discovery activities, resulting in the identification of a number of novel enzyme inhibitors. Many...

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Bibliographic Details
Main Authors: Alexander Krah, Gerhard Grüber, Peter J. Bond
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Current Research in Structural Biology
Subjects:
F-ATP synthase
TBAJ-876
Molecular dynamics simulations
Mycobacteria
Diarylquinolines
Bedaquiline
Online Access:http://www.sciencedirect.com/science/article/pii/S2665928X22000253

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http://www.sciencedirect.com/science/article/pii/S2665928X22000253

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