Chronic AMPK inactivation slows SHH medulloblastoma progression by inhibiting mTORC1 signaling and depleting tumor stem cells

Chronic AMPK inactivation slows SHH medulloblastoma progression by inhibiting mTORC1 signaling and depleting tumor stem cells

Summary: We show that inactivating AMPK in a genetic medulloblastoma model depletes tumor stem cells and slows progression. In medulloblastoma, the most common malignant pediatric brain tumor, drug-resistant stem cells co-exist with transit-amplifying cells and terminally differentiated neuronal pro...

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Bibliographic Details
Main Authors: Daniel Shiloh Malawsky, Taylor Dismuke, Hedi Liu, Ethan Castellino, Jay Brenman, Biplab Dasgupta, Andrey Tikunov, Timothy R. Gershon
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:iScience
Subjects:
Molecular biology
Cell biology
Sequence analysis
Cancer
Model organism
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223025208

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http://www.sciencedirect.com/science/article/pii/S2589004223025208

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