Dynamic Contrast-Enhanced and Diffusion MRI Show Rapid and Dramatic Changes in Tumor Microenvironment in Response to Inhibition of HIF-1α Using PX-478

Dynamic Contrast-Enhanced and Diffusion MRI Show Rapid and Dramatic Changes in Tumor Microenvironment in Response to Inhibition of HIF-1α Using PX-478

PX-478 is a new agent known to inhibit the hypoxiaresponsive transcription factor, HIF-1α, in experimental tumors. The current study was undertaken in preparation for clinical trials to determine which noninvasive imaging endpoint(s) is sensitive to this drug's actions. Dynamic contrast-enhance...

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Bibliographic Details
Main Authors: Bénédicte F. Jordan, Matthew Runquist, Natarajan Raghunand, Amanda Baker, Ryan Williams, Lynn Kirkpatrick, Garth Powis, Robert J. Gillies
Format: Article
Language:English
Published: Elsevier 2005-05-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
PX-478
HT-29 tumors
Dynamic Contrast-Enhanced Magnetic Resonance Imaging
Diffusion Magnetic Resonance Imaging
molecular imaging
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558605800545

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http://www.sciencedirect.com/science/article/pii/S1476558605800545

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