Valve Endothelial Cell Exposure to High Levels of Flow Oscillations Exacerbates Valve Interstitial Cell Calcification

Valve Endothelial Cell Exposure to High Levels of Flow Oscillations Exacerbates Valve Interstitial Cell Calcification

The aortic valve facilitates unidirectional blood flow to the systemic circulation between the left cardiac ventricle and the aorta. The valve’s biomechanical function relies on thin leaflets to adequately open and close over the cardiac cycle. A monolayer of valve endothelial cells (VECs) resides o...

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Bibliographic Details
Main Authors: Chia-Pei Denise Hsu, Alexandra Tchir, Asad Mirza, Daniel Chaparro, Raul E. Herrera, Joshua D. Hutcheson, Sharan Ramaswamy
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Bioengineering
Subjects:
oscillatory flow
shear stress
valve calcification
paracrine signaling
Online Access:https://www.mdpi.com/2306-5354/9/8/393

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https://www.mdpi.com/2306-5354/9/8/393

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