T-Type Ca<sup>2+</sup> Enhancer SAK3 Activates CaMKII and Proteasome Activities in Lewy Body Dementia Mice Model

T-Type Ca<sup>2+</sup> Enhancer SAK3 Activates CaMKII and Proteasome Activities in Lewy Body Dementia Mice Model

Lewy bodies are pathological characteristics of Lewy body dementia (LBD) and are composed of α-synuclein (α-Syn), which is mostly degraded via the ubiquitin–proteasome system. More importantly, 26S proteasomal activity decreases in the brain of LBD patients. We recently introduced a T-type calcium c...

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Bibliographic Details
Main Authors: Jing Xu, Ichiro Kawahata, Hisanao Izumi, Kohji Fukunaga
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
alpha-synuclein
Lewy body dementia
proteasome activity
Alzheimer’s disease
amyloid β plaque
SAK3
Online Access:https://www.mdpi.com/1422-0067/22/12/6185

Internet

https://www.mdpi.com/1422-0067/22/12/6185

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