Clinical impact of carbapenems in critically ill patients with valproic acid therapy: A propensity-matched analysis

Clinical impact of carbapenems in critically ill patients with valproic acid therapy: A propensity-matched analysis

BackgroundValproic acid (VPA) is one of the most widely used broad-spectrum antiepileptic drugs, and carbapenems (CBPs) remain the drug of choice for severe infection caused by multidrug-resistant bacteria in critically ill patients. The interaction between VPA and CBPs can lead to a rapid depletion...

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Bibliographic Details
Main Authors: Shu-Chen Hsiao, Wei-Hung Lai, I-Ling Chen, Fu-Yuan Shih
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Neurology
Subjects:
carbapenem
valproic acid
drug-drug interaction
critical care outcome
status epilepticus
mortality
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2023.1069742/full

Internet

https://www.frontiersin.org/articles/10.3389/fneur.2023.1069742/full

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