Transgenic expression of human LAMA5 suppresses murine Lama5 mRNA and laminin α5 protein deposition.

Transgenic expression of human LAMA5 suppresses murine Lama5 mRNA and laminin α5 protein deposition.

Laminin α5 is required for kidney glomerular basement membrane (GBM) assembly, and mice with targeted deletions of the Lama5 gene fail to form glomeruli. As a tool to begin to understand factors regulating the expression of the LAMA5 gene, we generated transgenic mice carrying the human LAMA5 locus...

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Bibliographic Details
Main Authors: Brooke M Steenhard, Adrian Zelenchuk, Larysa Stroganova, Kathryn Isom, Patricia L St John, Glen K Andrews, Kenneth R Peterson, Dale R Abrahamson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3168496?pdf=render

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http://europepmc.org/articles/PMC3168496?pdf=render

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