Eicosanoid lipidome activation in post-mortem brain tissues of individuals with APOE4 and Alzheimer’s dementia

Eicosanoid lipidome activation in post-mortem brain tissues of individuals with APOE4 and Alzheimer’s dementia

Abstract Background Chronic neuroinflammation is one of the hallmarks of late-onset Alzheimer’s disease (AD) dementia pathogenesis. Carrying the apolipoprotein ε4 (APOE4) allele has been associated with an accentuated response to brain inflammation and increases the risk of AD dementia progression....

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Bibliographic Details
Main Authors: Brandon Ebright, Isaac Assante, Roy A. Poblete, Shaowei Wang, Marlon V. Duro, David A. Bennett, Zoe Arvanitakis, Stan G. Louie, Hussein N. Yassine
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease
ApoE
Lipidomics
Inflammation
Online Access:https://doi.org/10.1186/s13195-022-01084-7

Internet

https://doi.org/10.1186/s13195-022-01084-7

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