Opioids Impair Intestinal Epithelial Repair in HIV-Infected Humanized Mice

Opioids Impair Intestinal Epithelial Repair in HIV-Infected Humanized Mice

Intestinal barrier dysfunction and subsequent microbial translocation play crucial roles in persistent immune activation leading to HIV disease progression. Opioid use is associated with worse outcome in HIV-infected patients. The exacerbated disease progression by opioids is mainly driven by excess...

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Bibliographic Details
Main Authors: Jingjing Meng, Santanu Banerjee, Li Zhang, Greg Sindberg, Shamsudheen Moidunny, Bin Li, David J. Robbins, Mohit Girotra, Bradley Segura, Sundaram Ramakrishnan, Sabita Roy
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Immunology
Subjects:
opioids
HIV
gut microbiota
BLT mice
intestinal organoid
notch
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02999/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02999/full

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