Dimethyl fumarate inhibits necroptosis and alleviates systemic inflammatory response syndrome by blocking the RIPK1-RIPK3-MLKL axis

Dimethyl fumarate inhibits necroptosis and alleviates systemic inflammatory response syndrome by blocking the RIPK1-RIPK3-MLKL axis

Necroptosis has been implicated in various inflammatory diseases including tumor-necrosis factor-α (TNF-α)-induced systemic inflammatory response syndrome (SIRS). Dimethyl fumarate (DMF), a first-line drug for treating relapsing-remitting multiple sclerosis (RRMS), has been shown to be effective aga...

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Bibliographic Details
Main Authors: Fu-li Shi, Li-sha Yuan, Tak-sui Wong, Qing Li, Ya-ping Li, Rong Xu, Yi-ping You, Tao Yuan, Hong-rui zhang, Zi-jian Shi, Qing-bing Zha, Bo Hu, Xian-hui He, Dong-yun Ouyang
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Pharmacological Research
Subjects:
Dimethyl fumarate
Necroptosis
Reverse electron transport
RIPK3
MLKL
Systemic inflammatory response syndrome
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661823000531

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http://www.sciencedirect.com/science/article/pii/S1043661823000531

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