Hydrophilic Monomethyl Auristatin E Derivatives as Novel Candidates for the Design of Antibody-Drug Conjugates

Antibody-drug conjugates (ADCs) are promising state-of-the-art biopharmaceutical drugs for selective drug-delivery applications and the treatment of diseases such as cancer. The idea behind the ADC technology is remarkable as it combines the highly selective targeting capacity of monoclonal antibodi...

Full description

Bibliographic Details
Main Authors: Filip S. Ekholm, Suvi-Katriina Ruokonen, Marina Redón, Virve Pitkänen, Anja Vilkman, Juhani Saarinen, Jari Helin, Tero Satomaa, Susanne K. Wiedmer
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Separations
Subjects:
Online Access:http://www.mdpi.com/2297-8739/6/1/1