Boosting cisplatin chemotherapy by nanomotor-enhanced tumor penetration and DNA adducts formation

Boosting cisplatin chemotherapy by nanomotor-enhanced tumor penetration and DNA adducts formation

Abstract Despite many nano-based strategies devoted to delivering cisplatin for tumor therapy, its clinical benefits are compromised by poor tissue penetration and limited DNA adducts formation of the drug. Herein, a cisplatin loading nanomotor based janus structured Ag-polymer is developed for cisp...

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Bibliographic Details
Main Authors: Lihua Xu, Kaixiang Zhang, Xing Ma, Yingying Li, Yajie Jin, Chenglin Liang, Yong Wang, Wendi Duan, Hongling Zhang, Zhenzhong Zhang, Jinjin Shi, Junjie Liu, Yunlong Wang, Wentao Li
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Journal of Nanobiotechnology
Subjects:
Cisplatin chemotherapy
Nanomotor
Tumor penetration
DNA adduct
Ion regulation
Online Access:https://doi.org/10.1186/s12951-022-01622-3

Internet

https://doi.org/10.1186/s12951-022-01622-3

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