Hypoxic tumor environments exhibit disrupted collagen I fibers and low macromolecular transport.

Hypoxic tumor environments exhibit disrupted collagen I fibers and low macromolecular transport.

Hypoxic tumor microenvironments result in an aggressive phenotype and resistance to therapy that lead to tumor progression, recurrence, and metastasis. While poor vascularization and the resultant inadequate drug delivery are known to contribute to drug resistance, the effect of hypoxia on molecular...

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Bibliographic Details
Main Authors: Samata M Kakkad, Marie-France Penet, Alireza Akhbardeh, Arvind P Pathak, Meiyappan Solaiyappan, Venu Raman, Dieter Leibfritz, Kristine Glunde, Zaver M Bhujwalla
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3861360?pdf=render

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http://europepmc.org/articles/PMC3861360?pdf=render

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