Tissue Inhibitor of Metalloproteases 3 (TIMP-3): In Vivo Analysis Underpins Its Role as a Master Regulator of Ectodomain Shedding

The proteolytical cleavage of transmembrane proteins with subsequent release of their extracellular domain, so-called ectodomain shedding, is a post-translational modification that plays an essential role in several biological processes, such as cell communication, adhesion and migration. Metallopro...

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Bibliographic Details
Main Authors: Donatella Pia Spanò, Simone Dario Scilabra
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Membranes
Subjects:
Online Access:https://www.mdpi.com/2077-0375/12/2/211