Binding kinetics of ten small-molecule drug candidates on SARS-CoV-2 3CLpro revealed by biomolecular simulations
3CL protease (3CLpro) is the main protease (Mpro) found in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which cuts the coronavirus polyprotein at eleven conserved sites and is essential for the virus replication. Therefore, 3CLpro has been widely used as a promising drug target. Man...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-12-01
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| Series: | Medicine in Novel Technology and Devices |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590093523000528 |