Inhibiting the compensatory elevation of xCT collaborates with disulfiram/copper-induced GSH consumption for cascade ferroptosis and cuproptosis

Inhibiting the compensatory elevation of xCT collaborates with disulfiram/copper-induced GSH consumption for cascade ferroptosis and cuproptosis

Hepatocellular carcinoma (HCC) is one of the most prevalent malignant tumors and the fourth leading cause of cancer-related death globally, which is characterized by complicated pathophysiology, high recurrence rate, and poor prognosis. Our previous study has demonstrated that disulfiram (DSF)/Cu co...

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Bibliographic Details
Main Authors: Ping Zhang, Chaoting Zhou, Xueying Ren, Qiangan Jing, Yan Gao, Chen Yang, Yuhuan Shen, Yi Zhou, Wanye Hu, Feifan Jin, Haifeng Xu, Lingyan Yu, Yingchao Liu, Xiangmin Tong, Yanchun Li, Ying Wang, Jing Du
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Redox Biology
Subjects:
Hepatocellular carcinoma
DSF/Cu
Ferroptosis
Cuproptosis
xCT
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231723004081

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http://www.sciencedirect.com/science/article/pii/S2213231723004081

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