Exposure to low-dose perfluorooctanoic acid promotes hepatic steatosis and disrupts the hepatic transcriptome in mice

Exposure to low-dose perfluorooctanoic acid promotes hepatic steatosis and disrupts the hepatic transcriptome in mice

Objective: Perfluoroalkyl substances (PFAS) are man-made chemicals with demonstrated endocrine-disrupting properties. Exposure to perfluorooctanoic acid (PFOA) has been linked to disturbed metabolism via the liver, although the exact mechanism is not clear. Moreover, information on the metabolic eff...

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Bibliographic Details
Main Authors: Brecht Attema, Aafke W.F. Janssen, Deborah Rijkers, Evert M. van Schothorst, Guido J.E.J. Hooiveld, Sander Kersten
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Molecular Metabolism
Subjects:
PFOA
GenX
PPARα
Lipid metabolism
Dyslipidemia
NAFLD
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877822001715

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http://www.sciencedirect.com/science/article/pii/S2212877822001715

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