Type II collagen scaffolds repair critical-sized osteochondral defects under induced conditions of osteoarthritis in rat knee joints via inhibiting TGF-β-Smad1/5/8 signaling pathway

Type II collagen scaffolds repair critical-sized osteochondral defects under induced conditions of osteoarthritis in rat knee joints via inhibiting TGF-β-Smad1/5/8 signaling pathway

The bidirectional relationship between osteochondral defects (OCD) and osteoarthritis (OA), with each condition exacerbating the other, makes OCD regeneration in the presence of OA challenging. Type II collagen (Col2) is important in OCD regeneration and the management of OA, but its potential appli...

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Bibliographic Details
Main Authors: Xu Hu, Min Jin, Kang Sun, Zhen Zhang, Zhonglian Wu, Junli Shi, Peilai Liu, Hang Yao, Dong-An Wang
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2024-05-01
Series:Bioactive Materials
Subjects:
Osteoarthritis
Osteochondral defect
Tissue engineering
Type II collagen
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X24000537

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http://www.sciencedirect.com/science/article/pii/S2452199X24000537

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