Whole genome sequencing identifies novel mutations in malaria parasites resistant to artesunate (ATN) and to ATN + mefloquine combination

Whole genome sequencing identifies novel mutations in malaria parasites resistant to artesunate (ATN) and to ATN + mefloquine combination

IntroductionThe global evolution of resistance to Artemisinin-based Combination Therapies (ACTs) by malaria parasites, will severely undermine our ability to control this devastating disease.MethodsHere, we have used whole genome sequencing to characterize the genetic variation in the experimentally...

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Bibliographic Details
Main Authors: Gustavo Capatti Cassiano, Axel Martinelli, Melina Mottin, Bruno Junior Neves, Carolina Horta Andrade, Pedro Eduardo Ferreira, Pedro Cravo
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
plasmodium
drug resistance
artemisinin combination treatment
genomics
molecular dynamics simulations
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2024.1353057/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2024.1353057/full

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