Longitudinal High-Throughput Sequencing of the T-Cell Receptor Repertoire Reveals Dynamic Change and Prognostic Significance of Peripheral Blood TCR Diversity in Metastatic Colorectal Cancer During Chemotherapy

Longitudinal High-Throughput Sequencing of the T-Cell Receptor Repertoire Reveals Dynamic Change and Prognostic Significance of Peripheral Blood TCR Diversity in Metastatic Colorectal Cancer During Chemotherapy

Colorectal cancer (CRC) is a major cause of cancer mortality and morbidity. Despite advances in chemotherapy and targeted therapy, unsustainable clinical benefit was noted due to recurrence and therapy resistance. The immune status of the cancer patient may affect the effectiveness of disease treatm...

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Bibliographic Details
Main Authors: Yi-Tung Chen, Hung-Chih Hsu, Yun-Shien Lee, Hsuan Liu, Bertrand Chin-Ming Tan, Chia-Yin Chin, Ian Yi-Feng Chang, Chia-Yu Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Immunology
Subjects:
T cell repertoire
metastatic colorectal cancer
prognosis
peripheral blood
chemotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.743448/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.743448/full

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