HPLC-Based Purification and Isolation of Potent Anti-HIV and Latency Reversing Daphnane Diterpenes from the Medicinal Plant <i>Gnidia sericocephala</i> (<i>Thymelaeaceae</i>)

HPLC-Based Purification and Isolation of Potent Anti-HIV and Latency Reversing Daphnane Diterpenes from the Medicinal Plant <i>Gnidia sericocephala</i> (<i>Thymelaeaceae</i>)

Despite the success of combination antiretroviral therapy (cART), HIV persists in low- and middle-income countries (LMIC) due to emerging drug resistance and insufficient drug accessibility. Furthermore, cART does not target latently-infected CD4+ T cells, which represent a major barrier to HIV erad...

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Main Authors: Babalwa Tembeni, Amanda Sciorillo, Luke Invernizzi, Thomas Klimkait, Lorena Urda, Phanankosi Moyo, Dashnie Naidoo-Maharaj, Nathan Levitties, Kwasi Gyampoh, Guorui Zu, Zhe Yuan, Karam Mounzer, Siphathimandla Nkabinde, Magugu Nkabinde, Nceba Gqaleni, Ian Tietjen, Luis J. Montaner, Vinesh Maharaj
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Viruses
Subjects:
antiretroviral therapy
HIV
<i>Gnidia sericocephala</i>
daphnane-type compounds
reverse HIV latency
protein kinase C activation
Online Access:https://www.mdpi.com/1999-4915/14/7/1437

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https://www.mdpi.com/1999-4915/14/7/1437

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