Substituted Aryl Benzylamines as Potent and Selective Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 3

Substituted Aryl Benzylamines as Potent and Selective Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 3

17β-Hydroxysteroid dehydrogenase type 3 (17β-HSD3) is expressed at high levels in testes and seminal vesicles; it is also present in prostate tissue and involved in gonadal and non-gonadal testosterone biosynthesis. The enzyme is membrane-bound, and a crystal structure is not yet available. Selectiv...

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Bibliographic Details
Main Authors: Nigel Vicker, Helen V. Bailey, Joanna M. Day, Mary F. Mahon, Andrew Smith, Helena J. Tutill, Atul Purohit, Barry V. L. Potter
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Molecules
Subjects:
prostate cancer
synthesis
dehydrogenase
homology modelling
chiral chromatography
X-ray crystallography
Online Access:https://www.mdpi.com/1420-3049/26/23/7166

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https://www.mdpi.com/1420-3049/26/23/7166

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