ACT001 improved cardiovascular function in septic mice by inhibiting the production of proinflammatory cytokines and the expression of JAK-STAT signaling pathway

ACT001 improved cardiovascular function in septic mice by inhibiting the production of proinflammatory cytokines and the expression of JAK-STAT signaling pathway

Sepsis is a life-threatening multiple organ dysfunction syndrome (MODS) caused by a microbial infection that leads to high morbidity and mortality worldwide. Sepsis-induced cardiomyopathy (SIC) and coagulopathy promote the progression of adverse outcomes in sepsis. Here, we reported that ACT001, a m...

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Bibliographic Details
Main Authors: Zhen Peng, Xiaolong Lv, Xintong Wang, Ting Shang, Jing Chang, Khalid Salahdiin, Yue Guo, Zhisen Zhang, Ru Shen, Ming Lyu, Shuang He, Jian Yang, Yuefei Wang, Xiumei Gao, Yan Zhu, Yuxin Feng
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Pharmacology
Subjects:
ACT001
septic shock
sepsis-induced cardiomyopathy
cecal ligation and puncture
coagulation
JAK-STAT signaling pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1265177/full

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https://www.frontiersin.org/articles/10.3389/fphar.2023.1265177/full

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