Dependency of Tamoxifen Sensitive and Resistant ER<sup>+</sup> Breast Cancer Cells on Semaphorin 3C (SEMA3C) for Growth

Dependency of Tamoxifen Sensitive and Resistant ER<sup>+</sup> Breast Cancer Cells on Semaphorin 3C (SEMA3C) for Growth

Estrogen receptor positive (ER<sup>+</sup>) breast cancer (BCa) accounts for the highest proportion of breast cancer-related deaths. While endocrine therapy is highly effective for this subpopulation, endocrine resistance remains a major challenge and the identification of novel targets...

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Bibliographic Details
Main Authors: Satyam Bhasin, Christopher Dusek, James W. Peacock, Artem Cherkasov, Yuzhuo Wang, Martin Gleave, Christopher J. Ong
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Cells
Subjects:
ER<sup>+</sup> breast cancer
Semaphorin 3C
plexin-B1
siRNA knockdown
Akt-MAPK signaling
apoptosis
Online Access:https://www.mdpi.com/2073-4409/12/13/1715

Internet

https://www.mdpi.com/2073-4409/12/13/1715

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