Structure-Activity Relationship Study of the Neuritogenic Potential of the Glycan of Starfish Ganglioside LLG-3 ‡

Structure-Activity Relationship Study of the Neuritogenic Potential of the Glycan of Starfish Ganglioside LLG-3 ‡

LLG-3 is a ganglioside isolated from the starfish Linchia laevigata. To clarify the structure-activity relationship of the glycan of LLG-3 toward rat pheochromocytoma PC12 cells in the presence of nerve growth factor, a series of mono- to tetrasaccharide glycan derivatives were chemically synthesize...

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Bibliographic Details
Main Authors: Megumi Yamagishi, Ritsuko Hosoda-Yabe, Hideki Tamai, Miku Konishi, Akihiro Imamura, Hideharu Ishida, Tomio Yabe, Hiromune Ando, Makoto Kiso
Format: Article
Language:English
Published: MDPI AG 2015-12-01
Series:Marine Drugs
Subjects:
ganglioside
starfish
neurite outgrowth
PC12 cell
SH-SY5Y cell
structure-activity relationship
MAPK/ERK signaling
Online Access:http://www.mdpi.com/1660-3397/13/12/7062

Internet

http://www.mdpi.com/1660-3397/13/12/7062

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