SNP imputation bias reduces effect size determination

SNP imputation bias reduces effect size determination

Imputation is a commonly used technique that exploits linkage disequilibrium to infer missing genotypes in genetic datasets, using a well characterized reference population. While there is agreement that the reference population has to match the ethnicity of the query dataset, it is common practice...

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Bibliographic Details
Main Authors: Pouya eKhankhanian, Lennox eDin, Stacy J Caillier, Pierre-Antoine eGourraud, Sergio E Baranzini
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-02-01
Series:Frontiers in Genetics
Subjects:
GWAS
SNP
accuracy
Imputation
Bias Correction
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2015.00030/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fgene.2015.00030/full

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