Quantification of ongoing APOBEC3A activity in tumor cells by monitoring RNA editing at hotspots

Quantification of ongoing APOBEC3A activity in tumor cells by monitoring RNA editing at hotspots

The DNA cytosine deaminases APOBEC3A and APOBEC3B have emerged from cancer genomics studies as drivers of mutation in cancers and tumor heterogeneity. Here the authors present a computational approach to identify the RNA mutations specifically driven by APOBEC3A, and developed an RNA mutation-based...

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Bibliographic Details
Main Authors: Pégah Jalili, Danae Bowen, Adam Langenbucher, Shinho Park, Kevin Aguirre, Ryan B. Corcoran, Angela G. Fleischman, Michael S. Lawrence, Lee Zou, Rémi Buisson
Format: Article
Language:English
Published: Nature Portfolio 2020-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-16802-8

Internet

https://doi.org/10.1038/s41467-020-16802-8

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