Self-Assembled Micelles Composed of Doxorubicin Conjugated Y-Shaped PEG-Poly(glutamic acid)2 Copolymers via Hydrazone Linkers

Self-Assembled Micelles Composed of Doxorubicin Conjugated Y-Shaped PEG-Poly(glutamic acid)2 Copolymers via Hydrazone Linkers

In this work, micelles composed of doxorubicin-conjugated Y-shaped copolymers (YMs) linked via an acid-labile linker were constructed. Y-shaped copolymers of mPEG-b-poly(glutamate-hydrazone-doxorubicin)2 and linear copolymers of mPEG-b-poly(glutamate-hydrazone-doxorubicin) were synthesized and chara...

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Bibliographic Details
Main Authors: Bowen Sui, Hui Xu, Jian Jin, Jingxin Gou, Jingshuo Liu, Xing Tang, Yu Zhang, Jinghua Xu, Hongfeng Zhang, Xiangqun Jin
Format: Article
Language:English
Published: MDPI AG 2014-08-01
Series:Molecules
Subjects:
miktoarm-star copolymer
conjugate
doxorubicin
pH-responsive drug release
drug delivery
Online Access:http://www.mdpi.com/1420-3049/19/8/11915

Internet

http://www.mdpi.com/1420-3049/19/8/11915

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