Endoplasmic reticulum microenvironment and conserved histidines govern ELOVL4 fatty acid elongase activity

Endoplasmic reticulum microenvironment and conserved histidines govern ELOVL4 fatty acid elongase activity

Autosomal dominant Stargardt-like macular dystrophy (STGD3) in humans results from mutations in elongation of very long chain FAs-like 4 (ELOVL4), which leads to vision loss in young adults. ELOVL4 is an integral endoplasmic reticulum (ER) protein that mediates the elongation of very long chain (VLC...

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Bibliographic Details
Main Authors: Sreemathi Logan, Martin-Paul Agbaga, Michael D. Chan, Richard S. Brush, Robert E. Anderson
Format: Article
Language:English
Published: Elsevier 2014-04-01
Series:Journal of Lipid Research
Subjects:
mutant
lipid metabolism
retinal degeneration
autosomal dominant
elongation of very long chain fatty acids-like 4
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520376586

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http://www.sciencedirect.com/science/article/pii/S0022227520376586

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