Caspase-8 Deficient Osteoblastic Cells Display Alterations in Non-Apoptotic Pathways

Caspase-8 Deficient Osteoblastic Cells Display Alterations in Non-Apoptotic Pathways

Caspase-8 is the key component of the receptor-mediated (extrinsic) apoptotic pathway. Immunological localization of active caspase-8 showed its presence in osteoblasts, including non-apoptotic ones. Further in vivo exploration of caspase-8 functions in the bone is hindered by the fact that the casp...

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Bibliographic Details
Main Authors: Barbora Vesela, Michael Killinger, Kamila Rihova, Petr Benes, Eva Svandová, Adela Kratochvilová, Filip Trcka, Karel Kleparnik, Eva Matalova
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
osteogenesis
bone
CRISPR/cas9
apoptosis
autophagy
MC3T3-E1
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.794407/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2022.794407/full

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