Parallel genetics of regulatory sequences using scalable genome editing in vivo

Parallel genetics of regulatory sequences using scalable genome editing in vivo

Summary: How regulatory sequences control gene expression is fundamental for explaining phenotypes in health and disease. Regulatory elements must ultimately be understood within their genomic environment and development- or tissue-specific contexts. Because this is technically challenging, few regu...

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Bibliographic Details
Main Authors: Jonathan J. Froehlich, Bora Uyar, Margareta Herzog, Kathrin Theil, Petar Glažar, Altuna Akalin, Nikolaus Rajewsky
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Cell Reports
Subjects:
gene regulation
gene-regulatory elements
animal phenotype
Caenorhabditis elegans
in vivo
CRISPR-Cas9
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721003028

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http://www.sciencedirect.com/science/article/pii/S2211124721003028

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