Immunogenicity and Protective Potential of Mucosal Vaccine Formulations Based on Conserved Epitopes of Influenza A Viruses Fused to an Innovative Ring Nanoplatform in Mice and Chickens

Immunogenicity and Protective Potential of Mucosal Vaccine Formulations Based on Conserved Epitopes of Influenza A Viruses Fused to an Innovative Ring Nanoplatform in Mice and Chickens

Current inactivated vaccines against influenza A viruses (IAV) mainly induce immune responses against highly variable epitopes across strains and are mostly delivered parenterally, limiting the development of an effective mucosal immunity. In this study, we evaluated the potential of intranasal form...

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Bibliographic Details
Main Authors: Cynthia Calzas, Molida Mao, Mathilde Turpaud, Quentin Viboud, Joelle Mettier, Thomas Figueroa, Pierre Bessière, Antoine Mangin, Laura Sedano, Pierre-Louis Hervé, Romain Volmer, Mariette F. Ducatez, Steve Bourgault, Denis Archambault, Ronan Le Goffic, Christophe Chevalier
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Immunology
Subjects:
influenza A viruses
highly pathogenic avian influenza virus
mucosal vaccines
adjuvants
nanoparticles
M2e/HA2 subunit vaccines
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.772550/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.772550/full

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