MHC-I genotype drives early immune selection of oncogenic mutations

MHC-I genotype drives early immune selection of oncogenic mutations

MHC-I exposes the intracellular contents to immune cells for surveillance of cellular health. Due to high genomic variation, individuals' immune systems differ in their ability to expose and eliminate cancer-causing mutations. These personalized immune blind spots create specific oncogenic muta...

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Bibliographic Details
Main Authors: Rachel Marty, Nicola de Prisco, Hannah Carter, Joan Font-Burgada
Format: Article
Language:English
Published: Taylor & Francis Group 2018-03-01
Series:Molecular & Cellular Oncology
Subjects:
antigen presentation
cancer predisposition
cancer susceptibility prediction
cancer
human leukocyte antigen
immunology, immunoediting
immunotherapy
major histocompatibility complex
neoantigens
Online Access:http://dx.doi.org/10.1080/23723556.2017.1409863

Internet

http://dx.doi.org/10.1080/23723556.2017.1409863

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