MHC-I genotype drives early immune selection of oncogenic mutations
MHC-I exposes the intracellular contents to immune cells for surveillance of cellular health. Due to high genomic variation, individuals' immune systems differ in their ability to expose and eliminate cancer-causing mutations. These personalized immune blind spots create specific oncogenic muta...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2018-03-01
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| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2017.1409863 |
| _version_ | 1797677171964116992 |
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| author | Rachel Marty Nicola de Prisco Hannah Carter Joan Font-Burgada |
| author_facet | Rachel Marty Nicola de Prisco Hannah Carter Joan Font-Burgada |
| author_sort | Rachel Marty |
| collection | DOAJ |
| description | MHC-I exposes the intracellular contents to immune cells for surveillance of cellular health. Due to high genomic variation, individuals' immune systems differ in their ability to expose and eliminate cancer-causing mutations. These personalized immune blind spots create specific oncogenic mutation predispositions within patients and influence their prevalence across populations. |
| first_indexed | 2024-03-11T22:41:12Z |
| format | Article |
| id | doaj.art-ce5fcd253dc34489acfe18c8c1832e02 |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:41:12Z |
| publishDate | 2018-03-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-ce5fcd253dc34489acfe18c8c1832e022023-09-22T09:10:59ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562018-03-015210.1080/23723556.2017.14098631409863MHC-I genotype drives early immune selection of oncogenic mutationsRachel Marty0Nicola de Prisco1Hannah Carter2Joan Font-Burgada3Division of Medical Genetics, University of California San DiegoCancer Biology Program, Fox Chase Cancer CenterDivision of Medical Genetics, University of California San DiegoCancer Biology Program, Fox Chase Cancer CenterMHC-I exposes the intracellular contents to immune cells for surveillance of cellular health. Due to high genomic variation, individuals' immune systems differ in their ability to expose and eliminate cancer-causing mutations. These personalized immune blind spots create specific oncogenic mutation predispositions within patients and influence their prevalence across populations.http://dx.doi.org/10.1080/23723556.2017.1409863antigen presentationcancer predispositioncancer susceptibility predictioncancerhuman leukocyte antigenimmunology, immunoeditingimmunotherapymajor histocompatibility complexneoantigens |
| spellingShingle | Rachel Marty Nicola de Prisco Hannah Carter Joan Font-Burgada MHC-I genotype drives early immune selection of oncogenic mutations Molecular & Cellular Oncology antigen presentation cancer predisposition cancer susceptibility prediction cancer human leukocyte antigen immunology, immunoediting immunotherapy major histocompatibility complex neoantigens |
| title | MHC-I genotype drives early immune selection of oncogenic mutations |
| title_full | MHC-I genotype drives early immune selection of oncogenic mutations |
| title_fullStr | MHC-I genotype drives early immune selection of oncogenic mutations |
| title_full_unstemmed | MHC-I genotype drives early immune selection of oncogenic mutations |
| title_short | MHC-I genotype drives early immune selection of oncogenic mutations |
| title_sort | mhc i genotype drives early immune selection of oncogenic mutations |
| topic | antigen presentation cancer predisposition cancer susceptibility prediction cancer human leukocyte antigen immunology, immunoediting immunotherapy major histocompatibility complex neoantigens |
| url | http://dx.doi.org/10.1080/23723556.2017.1409863 |
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