Spontaneously Resolving Joint Inflammation Is Characterised by Metabolic Agility of Fibroblast-Like Synoviocytes

Spontaneously Resolving Joint Inflammation Is Characterised by Metabolic Agility of Fibroblast-Like Synoviocytes

Fibroblast-like synoviocytes (FLS) play an important role in maintaining joint homeostasis and orchestrating local inflammatory processes. When activated during injury or inflammation, FLS undergo transiently increased bioenergetic and biosynthetic demand. We aimed to identify metabolic changes whic...

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Bibliographic Details
Main Authors: Jane Falconer, Valentina Pucino, Sally A. Clayton, Jennifer L. Marshall, Sabrina Raizada, Holly Adams, Andrew Philp, Andrew R. Clark, Andrew Filer, Karim Raza, Stephen P. Young, Christopher D. Buckley
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Immunology
Subjects:
fibroblasts
arthritis
inflammation
metabolism
mitochondria
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.725641/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.725641/full

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