Synthesis of Chromen-4-One-Oxadiazole Substituted Analogs as Potent <i>β</i>-Glucuronidase Inhibitors

Synthesis of Chromen-4-One-Oxadiazole Substituted Analogs as Potent <i>β</i>-Glucuronidase Inhibitors

Chromen-4-one substituted oxadiazole analogs <b>1</b>&#8211;<b>19</b> have been synthesized, characterized and evaluated for <i>&#946;</i>-glucuronidase inhibition. All analogs exhibited a variable degree of <i>&#946;</i>-glucuronidase inhi...

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Bibliographic Details
Main Authors: Muhammad Taha, Fazal Rahim, Muhammad Ali, Muhammad Naseem Khan, Mohammed A. Alqahtani, Yasser A. Bamarouf, Mohammed Gollapalli, Rai Khalid Farooq, Syed Adnan Ali Shah, Qamar Uddin Ahmed, Zainul Amiruddin Zakaria
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Molecules
Subjects:
chromen-4-one
oxadiazole
synthesis
<i>β</i>-glucuronidase inhibition
molecular docking
SAR
Online Access:https://www.mdpi.com/1420-3049/24/8/1528

Internet

https://www.mdpi.com/1420-3049/24/8/1528

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