Patients’ Pharmacogenetic Characteristics and the Risk of Adverse Reactions to Non-Steroidal Anti-Inflammatory Drugs: Clinical Cases

Patients’ Pharmacogenetic Characteristics and the Risk of Adverse Reactions to Non-Steroidal Anti-Inflammatory Drugs: Clinical Cases

SCIENTIFIC RELEVANCE. The variability in patient response to non-steroidal anti-inflammatory drugs (NSAIDs) may be due to genetic polymorphisms. Decreased-function or non-functional CYP2C9 alleles are known to be significant contributors to response variability, and research is being conducted on th...

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Bibliographic Details
Main Authors: A. S. Zhiryakova, N. P. Denisenko, A. V. Kryukov, K. A. Akmalova, S. N. Tuchkova, K. B. Mirzaev, D. A. Sychev
Format: Article
Language:Russian
Published: Ministry of Health of the Russian Federation, Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products» 2022-03-01
Series:Безопасность и риск фармакотерапии
Subjects:
<i>cyp2c9</i>
<i>ptgs</i>
non-steroidal anti-inflammatory drugs
ketorolac
adverse drug reactions
nephrotoxicity
nsaid-induced gastrointestinal toxicity
gastrointestinal bleeding
pharmacogenetic testing
Online Access:https://www.risksafety.ru/jour/article/view/409

Internet

https://www.risksafety.ru/jour/article/view/409

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