Galactosylated hydroxyl‐polyamidoamine dendrimer targets hepatocytes and improves therapeutic outcomes in a severe model of acetaminophen poisoning‐induced liver failure

Galactosylated hydroxyl‐polyamidoamine dendrimer targets hepatocytes and improves therapeutic outcomes in a severe model of acetaminophen poisoning‐induced liver failure

Abstract Toxicity to hepatocytes caused by various insults including drugs is a common cause of chronic liver failure requiring transplantation. Targeting therapeutics specifically to hepatocytes is often a challenge since they are relatively nonendocytosing unlike the highly phagocytic Kupffer cell...

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Bibliographic Details
Main Authors: Joshua E. Porterfield, Rishi Sharma, Ambar Scarlet Jimenez, Nirnath Sah, Sean McCracken, Lucia Zhang, Hyoung‐Tae An, Seulki Lee, Sujatha Kannan, Anjali Sharma, Rangaramanujam M. Kannan
Format: Article
Language:English
Published: Wiley 2023-05-01
Series:Bioengineering & Translational Medicine
Subjects:
acetaminophen poisoning
dendrimers
drug delivery
hepatocytes targeting
liver injury
N‐acetyl cysteine
Online Access:https://doi.org/10.1002/btm2.10486

Internet

https://doi.org/10.1002/btm2.10486

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