Dehydroepiandrosterone Cocrystals with Improved Solubility and Bioavailability

Dehydroepiandrosterone Cocrystals with Improved Solubility and Bioavailability

Dehydroepiandrosterone (DHEA) is an FDA-approved food supplement used as an assisted reproductive sex hormone. The bioavailability is severely limited by its poor solubility (23 µg/mL). Herein, we aimed to modulate its solubility through cocrystallization. Eight cocrystals of DHEA with pyrocatechol...

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Bibliographic Details
Main Authors: Yihua Jiang, Yinxiang Cheng, Mengyuan Xia, Bingrui Zhang, Qiaoce Ding, Liye Lu, Jian-Rong Wang, Xuefeng Mei
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Pharmaceutics
Subjects:
DHEA
cocrystallization
crystal structure
solubility
bioavailability
Online Access:https://www.mdpi.com/1999-4923/14/11/2478

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https://www.mdpi.com/1999-4923/14/11/2478

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