Acute osimertinib exposure induces electrocardiac changes by synchronously inhibiting the currents of cardiac ion channels

Acute osimertinib exposure induces electrocardiac changes by synchronously inhibiting the currents of cardiac ion channels

Introduction: As the third generation of epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), osimertinib has demonstrated more significant cardiotoxicity than previous generations of EGFR-TKIs. Investigating the mechanism of osimertinib cardiotoxicity can provide a reference for a...

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Bibliographic Details
Main Authors: Peiwen Li, Xiaohui Tian, Gongxin Wang, Enshe Jiang, Yanming Li, Guoliang Hao
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Pharmacology
Subjects:
osimertinib
QT prolongation
cardiac electrophysiology
delayed conduction
ion channel
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1177003/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1177003/full

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