Loss of Protein Stability and Function Caused by P228L Variation in NADPH-Cytochrome P450 Reductase Linked to Lower Testosterone Levels

Loss of Protein Stability and Function Caused by P228L Variation in NADPH-Cytochrome P450 Reductase Linked to Lower Testosterone Levels

Cytochrome P450 oxidoreductase (POR) is the redox partner of steroid and drug-metabolising cytochromes P450 located in the endoplasmic reticulum. Mutations in POR cause a broad range of metabolic disorders. The POR variant rs17853284 (P228L), identified by genome sequencing, has been linked to lower...

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Bibliographic Details
Main Authors: Maria Natalia Rojas Velazquez, Mathias Noebauer, Amit V. Pandey
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:International Journal of Molecular Sciences
Subjects:
cytochrome P450
POR
congenital adrenal hyperplasia
metabolic disorders
CYP3A4
protein stability
Online Access:https://www.mdpi.com/1422-0067/23/17/10141

Internet

https://www.mdpi.com/1422-0067/23/17/10141

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