Identification of novel proteins for lacunar stroke by integrating genome-wide association data and human brain proteomes

Abstract Background Previous genome-wide association studies (GWAS) have identified numerous risk genes for lacunar stroke, but it is challenging to decipher how they confer risk for the disease. We employed an integrative analytical pipeline to efficiently transform genetic associations to identify...

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Bibliographic Details
Main Authors: Chengcheng Zhang, Fengqin Qin, Xiaojing Li, Xiangdong Du, Tao Li
Format: Article
Language:English
Published: BMC 2022-06-01
Series:BMC Medicine
Subjects:
Online Access:https://doi.org/10.1186/s12916-022-02408-y