Dual LSD1 and HDAC6 Inhibition Induces Doxorubicin Sensitivity in Acute Myeloid Leukemia Cells

Dual LSD1 and HDAC6 Inhibition Induces Doxorubicin Sensitivity in Acute Myeloid Leukemia Cells

Defects in epigenetic pathways are key drivers of oncogenic cell proliferation. We developed a LSD1/HDAC6 multitargeting inhibitor (iDual), a hydroxamic acid analogue of the clinical candidate LSD1 inhibitor GSK2879552. iDual inhibits both targets with IC<sub>50</sub> values of 540, 110,...

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Bibliographic Details
Main Authors: Ipek Bulut, Adam Lee, Buse Cevatemre, Dusan Ruzic, Roman Belle, Akane Kawamura, Sheraz Gul, Katarina Nikolic, A. Ganesan, Ceyda Acilan
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Cancers
Subjects:
epigenetics
histone deacetylases (HDACs)
lysine demethylases (KMDs)
multitargeting
combination therapy
acute myeloid leukemia
Online Access:https://www.mdpi.com/2072-6694/14/23/6014

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https://www.mdpi.com/2072-6694/14/23/6014

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