MUC1-EGFR crosstalk with IL-6 by activating NF-κB and MAPK pathways to regulate the stemness and paclitaxel-resistance of lung adenocarcinoma

MUC1-EGFR crosstalk with IL-6 by activating NF-κB and MAPK pathways to regulate the stemness and paclitaxel-resistance of lung adenocarcinoma

AbstractBackground The chemotherapy resistance often leads to chemotherapy failure. This study aims to explore the molecular mechanism by which MUC1 regulates paclitaxel resistance in lung adenocarcinoma (LUAD), providing scientific basis for future target selection.Methods The bioinformatics method...

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Bibliographic Details
Main Authors: Hongyu Xu, Zedong Du, Zhihui Li, Xianguo Liu, Xueting Li, Xuan Zhang, Jiayu Ma
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Annals of Medicine
Subjects:
MUC1
lung adenocarcinoma
cancer cell stemness
paclitaxel resistance
NF-κB
MAPK
Online Access:https://www.tandfonline.com/doi/10.1080/07853890.2024.2313671

Internet

https://www.tandfonline.com/doi/10.1080/07853890.2024.2313671

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