Altered Blood–Brain Barrier Dynamics in the C9orf72 Hexanucleotide Repeat Expansion Mouse Model of Amyotrophic Lateral Sclerosis

Altered Blood–Brain Barrier Dynamics in the C9orf72 Hexanucleotide Repeat Expansion Mouse Model of Amyotrophic Lateral Sclerosis

For peripherally administered drugs to reach the central nervous system (CNS) and treat amyotrophic lateral sclerosis (ALS), they must cross the blood–brain barrier (BBB). As mounting evidence suggests that the ultrastructure of the BBB is altered in individuals with ALS and in animal models of ALS...

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Bibliografische gegevens
Hoofdauteurs: Yijun Pan, Yoshiteru Kagawa, Jiaqi Sun, Bradley J. Turner, Cheng Huang, Anup D. Shah, Ralf B. Schittenhelm, Joseph A. Nicolazzo
Formaat: Artikel
Taal:English
Gepubliceerd in: MDPI AG 2022-12-01
Reeks:Pharmaceutics
Onderwerpen:
amyotrophic lateral sclerosis
blood–brain barrier
brain microvascular endothelial cells
C9orf72 gene
proteomics
Online toegang:https://www.mdpi.com/1999-4923/14/12/2803

Internet

https://www.mdpi.com/1999-4923/14/12/2803

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