Energy imbalance alters Ca2+ handling and excitability of POMC neurons

Energy imbalance alters Ca2+ handling and excitability of POMC neurons

Satiety-signaling, pro-opiomelanocortin (POMC)-expressing neurons in the arcuate nucleus of the hypothalamus play a pivotal role in the regulation of energy homeostasis. Recent studies reported altered mitochondrial dynamics and decreased mitochondria- endoplasmic reticulum contacts in POMC neurons...

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Bibliographic Details
Main Authors: Lars Paeger, Andreas Pippow, Simon Hess, Moritz Paehler, Andreas C Klein, Andreas Husch, Christophe Pouzat, Jens C Brüning, Peter Kloppenburg
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-08-01
Series:eLife
Subjects:
calcium
calcium handling
hypothalamus
obesity
POMC-neuron
Online Access:https://elifesciences.org/articles/25641

Internet

https://elifesciences.org/articles/25641

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