Cytostatic Effect of a Novel Mitochondria-Targeted Pyrroline Nitroxide in Human Breast Cancer Lines

Cytostatic Effect of a Novel Mitochondria-Targeted Pyrroline Nitroxide in Human Breast Cancer Lines

Mitochondria have emerged as a prospective target to overcome drug resistance that limits triple-negative breast cancer therapy. A novel mitochondria-targeted compound, HO-5114, demonstrated higher cytotoxicity against human breast cancer lines than its component-derivative, Mito-CP. In this study,...

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Bibliographic Details
Main Authors: Kitti Andreidesz, Aliz Szabo, Dominika Kovacs, Balazs Koszegi, Viola Bagone Vantus, Eszter Vamos, Mostafa Isbera, Tamas Kalai, Zita Bognar, Krisztina Kovacs, Ferenc Gallyas
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
MDA-MB-231
MCF7
mitochondrial membrane potential
mitochondrial energy metabolism
reactive oxygen species
invasive growth
Online Access:https://www.mdpi.com/1422-0067/22/16/9016

Internet

https://www.mdpi.com/1422-0067/22/16/9016

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