Biological and therapeutic implications of RKIP in Gastrointestinal Stromal Tumor (GIST): an integrated transcriptomic and proteomic analysis

Biological and therapeutic implications of RKIP in Gastrointestinal Stromal Tumor (GIST): an integrated transcriptomic and proteomic analysis

Abstract Background Gastrointestinal stromal tumors (GIST) represent a significant clinical challenge due to their metastatic potential and limited treatment options. Raf kinase inhibitor protein (RKIP), a suppressor of the MAPK signaling pathway, is downregulated in various cancers and acts as a me...

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Main Authors: Nathália Cristina Campanella, Izabela Natalia Faria Gomes, Ana Laura Vieira Alves, Leticia Ferro Leal, Adriane Feijó Evangelista, Marcela Nunes Rosa, Matias Eliseo Melendez, Viviane Aline Oliveira Silva, Richard Lucas Konichi Dias, Lucas Faria Abrahão-Machado, Iara Santana, Olga Martinho, Denise Peixoto Guimarães, Vitor Marcel Faça, Rui Manuel Reis
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Cancer Cell International
Subjects:
RKIP expression
Gene knockout
GIST
COL3A1
Collagen
Cell invasion
Online Access:https://doi.org/10.1186/s12935-023-03102-6

Internet

https://doi.org/10.1186/s12935-023-03102-6

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