Assessing the Role of a Malonamide Linker in the Design of Potent Dual Inhibitors of Factor Xa and Cholinesterases

Assessing the Role of a Malonamide Linker in the Design of Potent Dual Inhibitors of Factor Xa and Cholinesterases

The rational discovery of new peptidomimetic inhibitors of the coagulation factor Xa (fXa) could help set more effective therapeutic options (to prevent atrial fibrillation). In this respect, we explored the conformational impact on the enzyme inhibition potency of the malonamide bridge, compared to...

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Bibliographic Details
Main Authors: Rosa Purgatorio, Nicola Gambacorta, Francesco Samarelli, Gianfranco Lopopolo, Modesto de Candia, Marco Catto, Orazio Nicolotti, Cosimo D. Altomare
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Molecules
Subjects:
antithrombotic agents
<i>N</i>,<i>N</i>′-malonamides
fXa inhibitors
thrombin inhibitors
acetylcholinesterase
butyrylcholinesterase
Online Access:https://www.mdpi.com/1420-3049/27/13/4269

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https://www.mdpi.com/1420-3049/27/13/4269

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