Function and phylogeny support the independent evolution of an ASIC-like Deg/ENaC channel in the Placozoa

Abstract ASIC channels are bilaterian proton-gated sodium channels belonging to the large and functionally-diverse Deg/ENaC family that also includes peptide- and mechanically-gated channels. Here, we report that the non-bilaterian invertebrate Trichoplax adhaerens possesses a proton-activated Deg/E...

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Bibliographic Details
Main Authors: Wassim Elkhatib, Luis A. Yanez-Guerra, Tatiana D. Mayorova, Mark A. Currie, Anhadvir Singh, Maria Perera, Julia Gauberg, Adriano Senatore
Format: Article
Language:English
Published: Nature Portfolio 2023-09-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-023-05312-0